In today’s biotechnology, pharmaceutical, and logistics landscapes, ultra-low temperature (ULT) requirements are at an all-time high. Sensitive materials—ranging from blood plasma to cell cultures, vaccines, and specialized chemicals—demand stringent temperature control to maintain quality and potency. Cryometrix has positioned itself as a global leader in cryogenic storage and transportation, delivering a pioneering portfolio of liquid nitrogen (LN2) freezers, shippers, and chillers that redefine efficiency, reliability, and sustainability.
Built on a foundation of over 30 patents related to the use of liquid nitrogen, Cryometrix provides compressor-free refrigeration systems that drastically reduce energy consumption, streamline maintenance, and optimize throughput. Whether you need rapid blast freezing at -90°C, extended long-term storage at -160°C, or shipping solutions that maintain ultra-low temperatures for days on end, Cryometrix has a tailored answer for your specific application.
Harnessing Liquid Nitrogen Technology for Ultra-Low Temperatures
Central to Cryometrix’s success is the decision to eliminate mechanical compressors in favor of fully contained LN2 systems. Traditional compressor-based freezers often involve complex machinery, ozone-depleting chemicals, and high energy usage. By contrast, LN2 naturally boils at -196°C, offering an exceptionally low temperature ceiling without the environmental drawbacks of refrigerants.
1. Compressor-Free Operation
- Fewer moving parts significantly reduce mechanical failures, noise, and maintenance overhead.
- Eliminates the need for costly HVAC systems to dissipate heat from compressors.
2. Reduced Energy Costs
- LN2 freezers can use up to 90% less electricity than standard mechanical units, leading to major savings on operational expenses.
- No heat exhaust from compressors translates into additional energy conservation on facility cooling.
3. Eco-Friendly Performance
- Nitrogen is inert, non-toxic, and makes up over 75% of the Earth’s atmosphere.
- No reliance on chemical refrigerants like CFCs, freon, or other volatile compounds that can harm the environment.
4. Rapid Temperature Changes
- Achieves ultra-low temperatures far faster than compressor systems, easily cooling from ambient to -90°C or even -160°C in significantly less time.
- Ideal for high-throughput environments where every minute saved translates into higher productivity and profit.
Revolutionary Blast Freezing Solutions
Some industries—particularly plasma centers, research labs, and pharmaceutical operations—depend on blast freezing to lock in freshness, viability, or stability in record time. Cryometrix offers two specialized solutions designed to excel in these demanding settings.
The B-90: Breaking Barriers in Speed and Throughput
- Ultra-Fast Pull-Down: Reaches -90°C in just about 10 minutes, enabling rapid freeze/thaw cycles and maximizing throughput.
- Temperature Versatility: Adjustable from +40°C to -90°C for diverse freezing profiles.
- Reduced Maintenance: Elimination of compressors translates into minimal service requirements and lower long-term costs.
- Enhanced Data Logging: Tracks temperature, alarms, and user activity to maintain stringent quality control—crucial for regulated industries.
MB-90: Compact, High-Performance Freezing
- Chest-Style Form Factor: Ideal for laboratories and pilot-scale production runs, with a pull-down from ambient to -90°C in as little as three minutes.
- Energy-Efficient: Consumes only about 0.3 gallons of LN2 per hour when at steady state, making it cost-effective for continuous use.
- Adjustable Temperature Profiles: Perfect for R&D applications where freeze protocols need frequent fine-tuning.
Reliable Ultra-Low Temperature Storage
When long-term stability is paramount, Cryometrix’s upright freezers deliver consistent ultra-low temperatures without sacrificing accessibility or security.
T-90: Balancing Convenience and Efficiency
- Versatile Temperature Range: From +20°C down to -90°C, offering flexible storage conditions for a variety of materials.
- Fast Pull-Down: Ambient to -80°C in roughly 45 minutes, ideal for critical lab and biopharmaceutical applications where time is of the essence.
- High Capacity: Holds up to 72,000 vials, yet retains a minimal footprint due to its upright design.
- Energy Savings: Uses substantially less electricity than mechanical freezers, contributing to lower operational costs over its lifespan.
T-160: For the Deepest of Freezes
- Ultra-Low Temperatures: Capable of reaching -160°C, pushing the boundaries of conventional freezing solutions.
- Multiple Redundancies: Equipped with 7-day battery backup and dual LN2 valves, ensuring stable conditions even in the event of power outages.
- GMP-Friendly: Many T-160 units are used in cGMP processes, offering reliability, repeatability, and fast freeze times, all while meeting stringent regulatory requirements.
MC-135: Compact Chest Freezer for -140°C
- Chest-Style Design: Simplifies loading and unloading for smaller volume applications needing temperatures as low as -140°C.
- High Uniformity: Maintains a tight temperature uniformity of ±3°C, safeguarding product integrity throughout the payload bay.
- Small Footprint: Fits into labs with limited space while delivering robust freezing performance.
Shipping & Freight Solutions: Extending LN2 Benefits Beyond the Lab
Ensuring a reliable cold chain is critical when transporting temperature-sensitive items over long distances. Cryometrix addresses these needs with advanced shipping and freight solutions that overcome the common pitfalls of dry ice or compressor-based systems.
S-90 Low Temperature Shipper
- Up to 15 Days of -90°C: Maintains product stability without the hassle of packing and repacking dry ice.
- Self-Contained LN2 & Battery: Provides autonomous operation, recording real-time data for optimal traceability.
- No Direct LN2 Exposure: Eliminates risk to both personnel and shipped goods, improving safety and compliance.
- Secure Access: Pneumatic latching system controlled via touchscreen HMI prevents unauthorized door openings.
RMF-90 Freight Freezer
- Wide Temperature Range: From -40°C to +40°C, suitable for many different cargo categories, including perishable food items and medical products.
- Adaptable Transport: Engineered for both air and ground logistics, maintaining stable temperatures while on the move.
- Minimal Power Use: Compressor-free design radically cuts electricity consumption, reducing carbon footprint and operational expenses.
LN2 Supply and Operational Considerations
One frequently asked question regarding LN2-based systems concerns the supply and handling of liquid nitrogen. LN2 is widely available and produced in large industrial facilities by fractional distillation of air. Once on-site, it is typically stored in tanks or dewars at pressures between 30 and 150 psi. Cryometrix freezers require no special ventilation apart from standard workplace safety measures. In most cases, simply connecting a regulated LN2 supply line is sufficient for months, if not years, of seamless operation.
Moreover, LN2 is nonflammable and inert, eliminating some of the hazardous classifications faced by hydrocarbon refrigerants. Because Cryometrix uses contained LN2 systems, there is zero direct contact between nitrogen and stored goods—further minimizing contamination risks.
Cost-Efficient, Long-Term Reliability
One of the most compelling selling points for Cryometrix’s product line is the extensive service life these freezers offer. Traditional mechanical freezers often face higher maintenance demands and can fail more frequently over time. Cryometrix’s compressor-free designs, by contrast, feature very few moving parts. This simplicity translates directly into:
- Minimal Downtime: Less chance of mechanical breakdowns, fewer emergency repairs, and less operational interruption.
- Lower Total Cost of Ownership: Reduced utility bills, minimal parts replacement, and fewer service visits.
- 20-Year Warranty: A bold commitment that underscores Cryometrix’s confidence in the durability of its cooling systems.
Regulatory Compliance and Data Management
For many industries—especially pharmaceuticals and biotechnology—adherence to strict regulatory standards is non-negotiable. Cryometrix offers optional 21 CFR Part 11 compliance packages for models like the B-90, T-90, T-160, and more, ensuring that electronic records and signatures meet FDA guidelines.
- Data Logging: Automated recording of temperature profiles, alarms, and user actions.
- User Permissions: Multi-level user security that restricts setpoint changes or door access to authorized personnel.
- Audit Trails: Detailed historical logs that can be exported for compliance audits or process reviews.
Because data integrity is critical in GMP and clinical settings, Cryometrix ensures these logs are securely stored and easily retrievable, closing the loop on traceability and quality assurance.
Future-Focused Innovation
Cryometrix continually invests in R&D to refine its LN2-based solutions and to broaden its product lineup. As the demand for ever-colder temperatures and more efficient freezing systems rises—particularly in emerging fields like gene therapy, CAR-T cell storage, and advanced vaccine production—Cryometrix’s platform of LN2 technology is already proving indispensable. The company’s dedication to scalable, environmentally responsible cooling solutions positions it at the leading edge of cryogenic innovation.
Elevate Your Cold Chain: Partner with Cryometrix
From revolutionary blast freezers like the B-90 and MB-90 to state-of-the-art shipping solutions such as the S-90 Low Temperature Shipper and RMF-90 Freight Freezer, Cryometrix delivers a comprehensive set of LN2-based technologies that streamline operations, reduce costs, and secure valuable inventory. By prioritizing compressor-free designs, minimal energy consumption, rigorous data logging, and robust user security, Cryometrix addresses every pain point associated with ultra-low temperature applications.
Whether your goal is to boost throughput in a pharmaceutical production line, safeguard critical research samples in a lab environment, or ensure a reliable cold chain for sensitive products in transit, Cryometrix stands ready to meet your demands with unmatched speed, reliability, and value.
Experience the Cryometrix difference and elevate your cold-chain operations to new heights.
Contact Cryometrix to explore how these innovative LN2 solutions can transform your freezing, chilling, and shipping workflows, ensuring a future-ready approach to ultra-low temperature management.