Cryometrix T-135 Ultra-Low Temperature Freezer (-135°C)
Advanced -135°C Freezing with No Liquid Nitrogen Exposure
The Cryometrix T-135 Ultra-Low Temperature Freezer is a groundbreaking innovation in the field of cryogenic storage. Designed specifically for biopharmaceutical manufacturing, clinical research, and laboratory-grade ultra-cold storage, the T-135 provides an unprecedented blend of performance, safety, and sustainability.
Using closed-loop liquid nitrogen (LN2) cooling technology, the T-135 achieves temperatures as low as -135°C without direct LN2 exposure to users or materials. This eliminates the safety concerns, handling risks, and operational complexity traditionally associated with cryogenic storage systems.
Whether you need long-term preservation of biological samples, consistent cold chain storage, or integrated freezing capabilities for production processes, the Cryometrix T-135 offers a reliable, energy-efficient solution that exceeds regulatory and industry standards.
Key Advantages of the Cryometrix T-135
Safe and Controlled Ultra-Low Freezing
The T-135 replaces the dangerous practice of manually accessing vats of LN2 with a completely enclosed and indirect cooling system. This means:
- Zero operator exposure to LN2
- No product contamination risk
- Simplified safety and compliance protocols
It’s designed to meet or exceed cGMP (Current Good Manufacturing Practices) for pharmaceutical and biologics storage, with the option to support 21 CFR Part 11 electronic recordkeeping compliance.
Powerful Freezing Performance
Engineered with precision and consistency in mind, the Cryometrix T-135 reaches ultra-cold temperatures fast and maintains them with minimal fluctuation. Key performance specifications include:
- Temperature range: +20°C to -135°C
- Peak variation from setpoint: +2°C / -15°C
- Uniformity: ±5°C throughout the chamber
- Door open recovery: 10 minutes (from -80°C, 3-minute open)
Whether you’re freezing for process readiness or preserving high-value biologics, the T-135 delivers stable and repeatable results.
Designed for Compliance, Built for Convenience
The Cryometrix T-135 comes pre-qualified for GMP operations and is used extensively in pharmaceutical manufacturing environments. Every aspect of the design—from temperature validation to user access control—supports regulatory compliance and documentation needs.
Features Include:
- IQ/OQ/PQ validation documentation available
- 3 levels of user access control, up to 100 individual users
- 7-inch color touchscreen for intuitive operation
- Full onboard data logging, with manual export in CSV format
- Secure electronic logs for temperature, alarm, and access tracking
Optional packages support FDA 21 CFR Part 11 compliance, making the T-135 ideal for organizations managing clinical trial materials or commercial-grade biologics.
Sustainable and Cost-Efficient Freezing
One of the most compelling benefits of the Cryometrix T-135 is its dramatically reduced operational cost and environmental impact.
Energy Efficiency:
- Consumes up to 90% less electricity than mechanical compressor-based systems
- No HVAC required – generates no external heat
- No moving parts – minimal mechanical wear and reduced maintenance
Environmental Responsibility:
- Uses only nitrogen, a clean and inert gas making up 78% of Earth’s atmosphere
- No oils, CFCs, or chemical refrigerants
- Quiet and clean operation—ideal for noise-sensitive environments
In contrast to traditional compressor systems, the Cryometrix freezer operates without the need for costly HVAC support, noisy motors, or chemical coolants—contributing to a smaller carbon footprint and lower total cost of ownership.
Built-In Redundancy and Emergency Protection
The Cryometrix T-135 is equipped with advanced redundancy systems that safeguard your materials in the event of electrical failure, mechanical malfunction, or LN2 disruption.
Backup Systems:
- 7-day onboard battery backup – maintains control systems during power loss
- Manual emergency LN2 valve – allows passive operation until LN2 depletion
- Dual redundant LN2 control valves – ensures continued cooling if one fails
- Secure fail-safe shutoffs and alarm systems – alert users of performance anomalies
These systems help guarantee uninterrupted protection of your biological or pharmaceutical inventory, even in adverse facility conditions.
Flexible Storage with a Compact Footprint
Despite offering deep cryogenic temperatures and high-capacity storage, the Cryometrix T-135 is designed with facility efficiency in mind.
External Dimensions:
- Height: 83 inches (2110 mm)
- Width: 48.2 inches (1224 mm)
- Depth: 41.8 inches (1062 mm)
- Weight: 1,626 lbs (738 kg)
Interior Specifications:
- Volume: 4.2 cu ft (120 liters)
- Interior dimensions: 16.5 in H × 26 in W × 17 in D
- Material: 100% 304 stainless steel (interior and exterior)
- Shelving: Configurable every 0.5 inches; includes 6 adjustable stainless-steel shelves
The upright configuration makes it easy to reach samples quickly, reducing user fatigue, and improving productivity compared to chest-style freezers. It also saves floor space and can be placed against a wall with no clearance needed.
Sample and Packaging Capacity
With optimized design and advanced airflow for uniform cooling, the T-135 can store a wide range of sample containers, including:
Up to 57,600 vials (1.2–2 mL, internally threaded)
3L bag capacity: Up to 6 bags laid flat
6L bag capacity: Up to 3 bags laid flat
12L bags: Not supported in current configuration
Custom rack configurations available on request
Whether you’re storing blood, plasma, RNA, DNA, vaccines, proteins, or bulk biologic formulations, the T-135 offers flexible space management and secure sample integrity.
Applications and Use Cases
With optimized design and advanced airflow for uniform cooling, the T-135 can store a wide range of sample containers, including:
Biopharma Manufacturing:
- Long-term bulk biologic storage
- Freezing intermediates and drug substances
- Controlled cold chain management for GMP operations
LN2 Redundancy
- Cryopreservation of tissues, DNA/RNA, and cell lines
- Storage of research materials at extremely low temperatures
- Biorepository and sample bank environments
Cell and Gene Therapy:
- CAR-T therapy and stem cell storage
- Controlled freezing for viral vectors and lentivirus preparations
Clinical & Diagnostic Labs:
- Archiving of specimens and patient samples
- Secure backup for critical clinical trial materials
The T-135’s performance, flexibility, and compliance support make it a future-proof investment for any laboratory or manufacturing facility working with temperature-sensitive materials.
Power and Electrical Requirements
The Cryometrix T-135 operates using a standard electrical supply and LN2 source:
- Voltage: 120VAC
- Frequency: 60 Hz
- Amperage: 6.5 A (freeze mode); 16 A (thaw mode)
- Plug Type: NEMA 5-20
- LN2 Supply Pressure: 30–100 psi
- Inlet Type: CGA 295 male fitting
This flexibility enables installation in a wide range of facilities with minimal infrastructure requirements.
Certifications and Manufacturing
Sustainability Features:
- CE Compliant
- Designed and Manufactured in the USA
- 21 CFR Part 11 Optional Compliance Package
As a fully certified unit with optional FDA audit trail support, the T-135 ensures that your cryogenic processes remain fully aligned with international regulatory standards.
20-Year Cooling System Warranty
Cryometrix stands by the quality of its engineering. The T-135 comes with a 20-year warranty on the cooling system (parts only), underscoring its long-term durability and reliability. Few other ultra-low freezers on the market offer this level of protection.
Also included:
- Virtual technical support
- Replacement control valves
- U.S.-based service team and parts availability
The Future of Cryogenic Freezing
The Cryometrix T-135 is the next generation of ultra-low temperature storage—bringing together the power of indirect LN2 cooling, the simplicity of upright design, and the precision required for regulated environments. It is ideal for biotech firms, pharmaceutical manufacturers, clinical labs, and research organizations who demand dependable performance, full compliance, and smart sustainability.
Top Reasons to Choose the T-135:
- Reaches and maintains -135°C without LN2 exposure
- Safe and compliant for GMP and FDA-regulated operations
- Up to 90% energy savings over traditional ULT freezers
- Longest warranty in its class: 20 years
- Flexible, space-efficient upright design
- Built-in data logging and user-level access security
- Operates silently, with no need for HVAC or compressors
B-135 Ultra Low Temperature Freezer
Features
Performance
Exterior
Payload Bay Dimensions
Electrical
16 A in Thaw mode.