In today’s rapidly evolving pharmaceutical and biotechnology landscape, biologics are complex medications derived from living cells that drive innovation in disease treatment and prevention. However, their sensitivity to environmental conditions presents a significant challenge: maintaining strict temperature control throughout the transportation process. Any temperature excursion can degrade these products, resulting in lost efficacy, costly recalls, or potential harm to patients.
This is where Cryometrix sets itself apart by offering next-generation transportation solutions that redefine the standards of cold chain logistics. Their liquid nitrogen (LN2) based freezer systems, including the RMF-90 Freight Freezer and the S-90 Low Temperature Shipper, ensure safe, efficient, and eco-conscious biologic transportation for a globalized healthcare market.
The Critical Role of Temperature Control in Biologic Transportation
Unlike chemically synthesized pharmaceuticals, biologics such as monoclonal antibodies, vaccines, and gene therapies are highly sensitive to temperature fluctuations. Exposure to temperatures outside of the required range can result in:
- Loss of biological activity
- Structural degradation
- Contamination risk
- Regulatory compliance violations
To avoid these risks, cold chain logistics must ensure the maintenance of specific temperature ranges, often as low as -90°C, throughout the entire shipping process from manufacturing facilities to hospitals and clinics.
Traditional cold chain methods such as dry ice and mechanical freezers come with limitations. These include temperature variability, energy inefficiency, high maintenance, and risk of exposure to harmful refrigerants. Fortunately, recent technological advancements offer more reliable and sustainable alternatives.
Cryometrix RMF-90 Freight Freezer: Temperature Control Across Air and Ground Transport
Designed with innovation and precision, the RMF-90 Freight Freezer addresses the limitations of traditional shipping methods by delivering robust temperature-controlled logistics for both air and ground transport.
Highlight Features:
- Temperature Range: Maintains internal payload bay between -40°C to +40°C
- Extreme Ambient Tolerance: Functions reliably in environments from -40°C to +60°C
- Battery Backup: Over 48 hours of autonomous runtime at 4°C
- Thermal Performance: Rapid cool down at 1°C/min and warm-up at 0.05°C/min
- User Control & Access: 7” touchscreen interface with access for up to 30 unique users
- Security Features: Multi-level user authentication ensures cargo safety
- Payload Capacity: A generous 6,442 liters of storage volume
- Silent Operation: Compressor-free design minimizes noise and electrical load
- Sustainability: Operates on a low-power LN2 system with no harmful emissions
The RMF-90 is ideal for global shipping needs where consistent thermal performance is vital across diverse climatic conditions and long travel times.
Cryometrix S-90 Low Temperature Shipper: Revolutionizing Ultra-Cold Biologic Shipping
When biologics require storage and transit at ultra-low temperatures, the Cryometrix S-90 Shipper is the gold standard. It integrates upright LN2 freezer technology with an onboard power and nitrogen supply, providing autonomous performance during long-duration shipments.
Key Advantages:
- Setpoint Flexibility: Fully programmable between +20°C and -90°C
- Temperature Uniformity: ±3°C at -80°C ensures consistent product protection
- Extended Cold Chain Assurance: Maintains -80°C for up to 15 days without recharge
- Large Capacity: Accommodates up to 72,000 vials (33.5 cubic feet or 950 liters)
- Ramp Rates: Ambient to -80°C in under 60 minutes
- Security and Access: Up to 30 customizable user profiles with secure locking system
- Self-Contained Design: Integrated LN2 and battery modules allow for autonomous operation
- Data Logging: Tracks temperature, alarms, and user activity with USB export capability
- Zero LN2 Exposure: Closed nitrogen system prevents contact with both product and operator
The S-90 is not just a shipping solution. It is a portable, intelligent cold chain infrastructure.
The Power of Liquid Nitrogen-Based Cooling
One of the core technologies enabling both the RMF-90 and S-90 to outperform traditional freezers is liquid nitrogen. With a boiling point of -196°C, LN2 offers significant thermal advantages over traditional refrigerants like Freon or other hydrofluorocarbons (HFCs), which operate with far less efficient cooling thresholds.
Benefits of LN2 Cooling Technology:
- Compressor-Free Operation: Eliminates complex, failure-prone moving parts
- Energy Efficiency: Up to 90% lower energy consumption compared to mechanical units
- Silent Functionality: Ideal for laboratories, hospitals, and transportation without disturbing operations
- Emergency Readiness: Systems can maintain temperature without electricity
- Sustainability: Nitrogen emissions are non-toxic and already comprise 78% of the Earth’s atmosphere
In addition to performance, Cryometrix’s LN2 systems offer unmatched reliability in harsh conditions and extended shelf life, with fewer maintenance needs and long-term ROI for shipping operations.
Enhanced Safety and Compliance
Maintaining compliance with stringent regulatory requirements such as GxP, FDA, and EMA standards is critical in biologic transportation. Cryometrix units provide built-in features to support these demands:
- Data Integrity: Automatic logs with timestamped actions for auditing
- Programmable Access Levels: User-specific permissions reduce the risk of unauthorized tampering
- Emergency Protocols: Manual override valves and internal temperature monitoring ensure resilience during power failures
- Minimal Human Interaction Required: Automates much of the shipping process, reducing human error
Furthermore, the closed nitrogen system ensures that biologics are never directly exposed to LN2, preserving sample integrity without contamination or condensation risks.
Scalable and Space-Efficient Solutions
For organizations scaling their biologics production and distribution, space and resource constraints are critical considerations. Cryometrix units offer:
- Compact Footprint: The S-90 occupies less than 8 square feet of space
- Scalability: Minimal electrical demand allows users to deploy multiple units without infrastructure upgrades
- Stainless Steel Construction: Easy to clean, sterilize, and maintain, making it ideal for GMP environments
Whether for a growing biotech startup or a multinational pharmaceutical manufacturer, Cryometrix solutions fit seamlessly into logistics operations of any size.
Environmental Stewardship Meets Logistics
Cryometrix’s commitment to sustainability goes beyond energy efficiency. Unlike conventional freezers that rely on environmentally damaging refrigerants, Cryometrix units operate with clean, non-toxic nitrogen.
Environmental Benefits:
- No use of refrigerants or CFCs
- Zero ozone depletion potential
- Long-term usability with a 20-year cooling system warranty
- Low maintenance footprint that reduces waste, replacement parts, and service visits
With these features, Cryometrix systems contribute to greener pharmaceutical supply chains, a key objective in today’s ESG-conscious world.
Building the Future of Cold Chain Logistics
As biologics continue to dominate the pharmaceutical pipeline, ensuring their safe, stable, and cost-effective transport is more vital than ever. The Cryometrix RMF-90 and S-90 exemplify how intelligent engineering and sustainable technology can meet the industry’s most demanding logistical challenges.
With their innovative use of liquid nitrogen cooling, enhanced security protocols, autonomous operation, and compliance-ready features, these solutions provide unmatched value for anyone tasked with moving sensitive biologics across the globe.
Whether you’re shipping across continents or delivering critical therapies across town, Cryometrix ensures your biologics arrive just as potent as when they left the lab: secure, stable, and compliant.